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phenobarbital will decrease the extent or outcome of olanzapine/samidorphan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Powerful CYP3A4 inducers minimize levels of olanzapine and samidorphan by~50% and ~75% respectively.As a result of inconsistencies among the drug labels on DailyMed and also the tablet